Peer-reviewed Publications

Systems-analysis of RhoGEF/RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Müller PM, Rademacher J, Bagshaw RD, Wortmann C, Barth C, van Unen J, Alp KM, Guidice G, Eccles RL, Heinrich LE, Pascual-Vargas P, Sanchez-Castro M, Brandenburg L, Mbamalu G, Tucholska M, Spatt L, Wortmann C, Czajkowski MT, Welke RW, Zhang S, Nguyen V, Rrustemi T, Trnka P, Freitag K, Larsen B, Popp O, Mertins P, Gingras AC, Roth FP, Colwill K, Bakal C, Pertz O, Pawson T, Petsalaki E, Rocks O

Nat Cell Biology, 2020, Apr;22(4):498-511 F1000 recommended

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Interaction modulation through arrays of clustered methyl-arginine protein modifications

Woodsmith J, Casado-Medrano V, Benlasfer N, Eccles RL, Hutten S, Heine CL, Thormann V, Abou-Ajram C, Rocks O, Dormann D, Stelzl U

Life Sci Alliance, 2018 Sep 21;1(5)

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An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

Schrade K , Tröger J, Eldahshan A, Zühlke K, Abdul Azeez KR, Elkins JM , Neuenschwander  M , Oder A, Elkewedi  M, Jaksch S, Andrae K, Li J, Fernandes J, Müller PM, Grunwald S, Marino SF, Vukićević T, Eichhorst J, Wiesner B, Weber M, Kapiloff M, Rocks O, Daumke O, Wieland T, Knapp S, von Kries JP, Klussmann  E

PLoS One, 2018 Jan 26;13(1)

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Quantitative GTPase Affinity Purification Identifies Rho Family Protein Interaction Partners

Paul F, Zauber H, von Berg L, Rocks O, Daumke O, Selbach M

Mol Cell Proteomics, 2017 Jan;16(1):73-

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Bimodal antagonism of PKA signalling by ARHGAP36

Eccles RL, Czajkowski MT, Barth C, Müller PM, McShane E, Grunwald S, Beaudette P, Mecklenburg N, Volkmer R, Zühlke K, Dittmar G, Selbach M, Hammes A, Daumke O, Klussmann E, Urbé S, Rocks O.

Nat Commun, 2016 Oct 7;7:12963

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Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers

Arumughan A, Roske  Y, Barth C, Forero LL, Bravo-Rodriguez K, Redel A, Kostova S, McShane E, Opitz R, Faelber K, Rau K, Mielke T, Daumke O, Selbach M, Sanchez-Garcia E, Rocks O, Panáková D, Heinemann U, Wanker EE

Nat Commun, 2016 Oct 20;7:13047.

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The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration

Becker MS, Müller PM, Bajorat J, Schroeder A, Giaisi M, Amin E, Ahmadian MR, Rocks O, Köhler R, Krammer PH, Li-Weber M

Oncotarget, 2016 Aug 9;7(32):51908-51921

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A new role of the Rac-GAP b2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression

Casado-Medrano V, Barrio-Real L, García-Rostán G, Baumann M, Rocks O, Caloca MJ

Oncotarget, 2016 May 10;7(19):28301-19

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Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP

Gray EJ, Petsalaki E, James DA, Bagshaw RD, Stacey MM, Rocks O, Gingras AC, Pawson T

J Biol Chem, 2014 Dec 19;289(51):35397-408

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Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein

Fröhlich C, Grabiger S, Schwefel D, Faelber K, Rosenbaum E, Mears J, Rocks O, Daumke O

EMBO J, 2013 May 2;32(9):1280-92

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Structural insights into the mechanism of GTPase activation in the GIMAP family

Schwefel D, Arasu BS, Marino SF, Lamprecht B, Köchert K, Rosenbaum E, Eichhorst J, Wiesner B, Behlke J, Rocks O, Mathas S, Daumke O

Structure, 2013 Apr 2;21(4):550-9

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A roadmap to generate renewable protein binders to the human proteome

Colwill K; Renewable Protein Binder Working Group, Gräslund S

Nat Methods, 2011 May 15;8(7):551-8

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Regulation of Ras localization by acylation enables a mode of intracellular signal propagation

Lorentzen A, Kinkhabwala A, Rocks O, Vartak N, Bastiaens PI

Sci Signal, 2010 Sep 21;3(140) F1000 recommended

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Small-molecule inhibition of APT1 affects Ras localization and signaling

Dekker FJ*, Rocks O*, Vartak N, Menninger S, Hedberg C, Balamurugan R, Wetzel S, Renner S, Gerauer M, Schölermann B, Rusch M, Kramer JW, Rauh D, Coates GW, Brunsveld L, Bastiaens PI, Waldmann H

Nat Chem Biol, 2010 Jun;6(6):449-56 *Equal contributions

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The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins

Rocks O, Gerauer M, Vartak N, Koch S, Huang ZP, Pechlivanis M, Kuhlmann J, Brunsveld L, Chandra A, Ellinger B, Waldmann H, Bastiaens PI

Cell, 2010 Apr 30;141(3):458-71

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Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors

Rocks O, Peyker A, Bastiaens PI

Curr Opin Cell Biol, 2006 Aug;18(4):351-7

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An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

Rocks O, Peyker A, Kahms M, Verveer PJ, Koerner C, Lumbierres M, Kuhlmann J, Waldmann H, Wittinghofer A, Bastiaens PI

Science, 2005 Mar 18;307(5716):1746-52  F1000 recommended

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 Imaging activation of two Ras isoforms simultaneously in a single cell

Peyker A, Rocks O, Bastiaens PI

Chembiochem, 2005 Jan;6(1):78-85

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Red-edge anisotropy microscopy enables dynamic imaging of homo-FRET between green fluorescent proteins in cells

Squire A, Verveer PJ, Rocks O, Bastiaens PI

J Struct Biol, 2004, Jul;147(1):62-9

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Imaging protein interactions by FRET microscopy: FLIM measurements

Verveer PJ, Rocks O, Harpur AG, Bastiaens PI

CSH Protoc, 2006 Nov 1;2006(6)

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Imaging protein interactions by FRET microscopy: FRET measurements by acceptor photobleaching

Verveer PJ, Rocks O, Harpur AG, Bastiaens PI

CSH Protoc, 2006 Nov 1;2006(6)

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Imaging protein interactions by FRET microscopy: FRET measurements by sensitized emission

Verveer PJ, Rocks O, Harpur AG, Bastiaens PI

CSH Protoc, 2006 Nov 1;2006(6)

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FLIM measurements and frequency domain FLIM data analysis

Verveer PJ, Rocks O, Harpur AG, Bastiaens PI

CSH Protoc, 2006 Nov 1;2006(6)

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An experimental setup for frequency domain FLIM

Verveer PJ, Rocks O, Harpur AG, Bastiaens PI

CSH Protoc, 2006 Nov 1;2006(6)

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Measuring FRET by acceptor photobleaching

Verveer PJ, Rocks O, Harpur AG, Bastiaens PI

CSH Protoc. 2006 Nov 1;2006(6)

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Measuring FRET by sensitized emission

Verveer PJ, Rocks O, Harpur AG, Bastiaens PI

CSH Protoc, 2006 Nov 1;2006(6)

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EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation

Reynolds AR, Tischer C, Verveer PJ, Rocks O, Bastiaens PI.

Nat Cell Biol, 2003 May;5(5):447-53

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Structural domains required for channel function of the mouse transient receptor potential protein homologue TRP1beta

Engelke M, Friedrich O, Budde P, Schäfer C, Niemann U, Zitt C, Jüngling E, Rocks O, Lückhoff A, Frey J. FEBS Lett, 2002 Jul 17;523(1-3):193-9

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